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CHARCOT-MARIE-TOOTH DISEASE Of the several subtypes of Charcot-Marie-Tooth disease, a peripheral neuropathy characterised by distal muscle weakness and atrophy, linkage has recently been reported of the gene for the major subtype, hereditary motor and sensory neuropathy type 1, with markers on chromosome 1 in some families and chromosome 17 in others. If this genetic heterogeneity is established, then there are serious implications for presymptomatic and prenatal testing using flanking markers. Clinical geneticists knowing of families with multiple cases of Charcot-Marie-Tooth disease are requested to contact Dr Christine Van Broeckhoven, University of Antwerp, Department of Biochemistry, Building T, Universitetsplein 1, B-2610, Antwerp, Belgium, with a view to collaborative investigation. | ||||||