pharmacogenetics

Genetics in medicine 2 – adult life
Publication Date: November 2014
Author: AP Read, D Donnai and HR Middleton-Price
Publication contents:

Introduction; How genes can influence adult health; Simple versus complex inheritance; Complex inheritance and family risks; Genetic prediction in complex disease; Genetic risk and clinical practice; Adult medicine: the big challenges; Diabetes; Heart disease; Neurodegenerative diseases; Disorders of mental health; Cancer; Other conditions affecting adults; Disorders that arise through mutations

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Genetics in Medicine 3 – Precision Medicine
Publication Date: October 2016
Author: Helen Middleton‐Price, Andrew P Read, Dian Donnai
Publication contents:

Exploring the revolution in medicine built on a growing understanding of molecular mechanisms and the extraordinary advances in DNA sequencing technology. What should be in the laboratory report? Ethical considerations. Precision medicine treatments for rare diseases. Dietary management of genetic conditions. Enzyme replacement therapy. Drug treatments. Anti‐sense therapy. Gene therapy. Gene editing. Three‐parent embryos – preventing mitochondrial disease. Progress in stem‐cell therapies. Type I diabetes. Multiple sclerosis. Pharmacogenetics. How does genetic variation influence drug acƟon? Absorption, distribution, metabolism and elimination (ADME). The variable effect of a drug on its target molecule Adverse drug reactions. Companion diagnostics. Defining the cancer genome. Treatments in cancer. Precision drug treatments for cancer. Targeted therapies for cancer. Combating acquired resistance. Companion diagnostics in cancer treatment. Non‐surgical testing – ‘liquid biopsies’

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